Case Report Using 4% Fucoidan Cream for Recurrent Oral Herpes Labialis: Patient Symptoms Markedly Improved in Terms of Time to Healing and Time to Loss of Discomfort.
Oral herpes labialis is characterized as a recurrent condition with painful ulcerative eruptions varying from 2 mm to 2 cm in diameter on the mucous membranes of the mouth. Recurrent oral herpes labialis, typically caused by herpes simplex virus type-1, is believed to affect nearly 40% of the Japanese population.
As important factors in deciding treatment strategy, the diagnosis, clinical presentation, severity and medical
history are considered. The goal of treatment is rapid pain management and suppression of the inflammatory response.
Power Fucoidan Cream has been prepared as 4% fucoidan isolated from Nemacystus decipiens9 in a base comprising stearic acid glyceryl, lectin, adenosine triphosphate, sodium alginate and other components that enhance permeability.
Although, the medicinal uses of
fucoidan have been investigated from the perspectives of cosmetics and skin-care agents, few studies have focused on oral disease. The present investigation initially examined the use of PFC for the
treatment of symptomatic ROHL in two typical clinical cases involving pain upon eating and speaking and that had proven refractory to various medications.
The outcomes of topical PFC application were remarkable. The results of PFC therapy from only two
patients are difficult to interpret, because the observed responses
might have simply reflected the natural course of the disease rather
than the effects of medication.
Although the mechanisms have not yet been fully elucidated, we believe that fucoidan cream exerted
real therapeutic effects, because previously persistent lesions did not recur.
Dent Open J. 2017; 5(1): 6-10. doi: 10.17140/DOJ-5-135
