Clinical Profile and Management of Chronic Pancreatitis in Tertiary Care Centre.
Constant inflammation and irreversible pancreatic tissue destruction are hallmarks of the disease of chronic pancreatitis, which results in the gradual loss of both exocrine and endocrine function. It is a multifactorial disease, with a wide range of symptoms and geographic variation.
The incidence of CP in the western population ranges
from 8 to 10 cases yearly per 100,000 population, and the overall prevalence is 27.4 per 100,000 per year.
According to a recent survey conducted in various countries in the Asia-Pacific region,
CP is prevalent in Southern India, with 114-200 cases per 100,000
people. In the Indian subcontinent, there has been no systematic
nationwide study on the management of clinical profiles.
Some of the possible causes of CP include alcohol abuse (malignancy or stones), ductal obstruction, chemotherapy, and autoimmune diseases such as
SLE or pancreatitis. According to recent research, the disease may
be caused by a lack of certain vitamins and antioxidants. Drinking alcohol is the most common cause. Protein
secretion from acinar cells increases, resulting in ductal obstruction, acinar fibrosis, and atrophy as a result of the alcohol.
Chronic pancreatitis appears to be caused by a combination of genetic and environmental factors. Several genes have been
linked to pancreatitis susceptibility mutations. Impaired bicarbonate secretion, which is unable to respond to increased pancreatic
protein secretion, is one possibility. Plugs are formed within the
lobules and ducts as a result of this abundance of proteins. Calcification and stone formation are the results of this process. The
other theory proposes that digestive enzymes in the pancreas are
activated intraparenchymally.
Pancreas Open J. 2022; 5(1): 9-15. doi: 10.17140/POJ-5-114