Combination Treatment with a Novel Polyherbal Formulation and Metformin: A Single Blind Placebo-Controlled Study in Patients with T2DM and Cognitive Impairments
In developing countries, improvement in the health care has contributed to people living
healthier and longer lives. This has resulted in an increase in the world ageing population and
consequently an increase in age related disorders like dementia.
Dementia is debilitating disease which involves variety of conditions that develop
when nerve cells (neurons) in the brain die or do not function properly.
Alzheimer’s disease (AD) is accounted to be the most common form of dementia followed by vascular
dementia and mixed dementia. The symptoms include memory loss, changes in behaviour,
ability to think clearly, eventual impairment of one’s ability to carry out basic bodily functions such
as walking and swallowing, and ultimately lead to death.
This disease constitutes a great burden not only to the patients, but is also devastating for
the caregivers and is an enormous social and economic burden to the Society.
Pharmaceutical interventions so far have been directed towards amelioration of the symptoms,
no drug action stops the progression of the disease.
There are two types of diabetes mellitus; Type1 Diabetes Mellitus (T1DM) and Type 2
Diabetes Mellitus (T2DM), which differ in their etiology and clinical presentation.
T1DM is an autoimmune disease in which the insulin producing cells of the pancreas are
destroyed, and results in chronic hyperglycemia due to insulin
deficiency.
Combination Treatment with a Novel Polyherbal Formulation and Metformin: A Single Blind Placebo-Controlled Study in Patients with T2DM and Cognitive Impairments
Diabetes Res Open J. 2015; 1(4): 92-102. doi: 10.17140/DROJ-1-116
