Granuloma Annulare in Women: Evaluating the Annular Configuration in the Context of Germline Repair.
Granuloma annulare (GA) is characterized by the abrupt onset of annular plaques with central clearing in the skin. GA commonly occurs in the skin around joints in women in their later reproductive years. Cell biologists have outlined the mechanisms of organelle movement during cell stress. Microtubules and actin, which form the internal structure and lattice like transport system within the cell, are continually reorienting in response to cellular need. These needs may present internally, as a response to aneuploidy, or externally, in response to an allergen or infectious agent.
The process of germ line duplication is dynamic, staged, and has distinct architecture and polarity during meiosis. The process is error prone and aneuploidy is common. Aneuploidy increases with age, and is much less tolerated in women due to the additional maternal responsibilities for growth in the early embryo. Aneuploidy activates a pause mechanism that stops cell division to allow time for the microtubules to capture and correct the attachments between chromosomes and the central spindle. Correctly attached chromosomes confer stability and allow the development of a pulling force between the poles. The generation of force pulls the spindle apart and cell division is completed.
Several drug classes, taxanes, colchicine, chloroquine, and others, specifically target structure/function relationships in the intracellular cytoskeleton for therapeutic use in cancer, gout and other conditions. Drug lists can also provide additional information on underlying health issues and access to care.
Women Health Open J. 2018; 4(1): 11-14. doi: 10.17140/WHOJ-4-127
