Halting Coronavirus Replication.
Sirtuin 1 (SIRT1) inhibitors can reduce replication of many viruses with certain characteristics similar to those of coronaviruses, while the p53 protein is another important factor in the down-regulation of viral growth. Tenovin is a class of small molecules that inhibit Sirtuin 1 and 2, in addition to activating the p53 protein, by means of regulating the interactions used by coronaviruses as a self-defense mechanism. By blocking virus growth and continuous replication, with already tested antiviral medicines, the promise of coronavirus disease 2019 (COVID-19) eradication exists.
From here, you can draw up a list of currently available interventions or known mechanisms of action to reduce the expression of ACE2 activity, in order to avoid (in whole or in part)
the entry of the virus into the subject under attack, but not only that. It is also possible that, by lowering its endo-ribonucleic activity to reduce the ability of the virus to reproduce.
Among the various other viruses that respond by slowing their growth, there is just middle east respiratory syndrome-coronavirus. The YDL042C/SIR2 yeast gene is a suppressor of ORF4a
function. When SIRT1 is inhibited by either chemical or genetic manipulation, there is a reduction of MERS-CoV replication. Moreover, ORF4a inhibited SIRT1-mediated modulation of
NF-κB signaling, demonstrating a functional link between ORF4a and SIRT1 in mammalian cells. Hypothetic useful drugs in Covid-19 fight also interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in inhibition of cytokine production and modulation of certain co-stimulatory molecules.
Epidemiol Open J. 2020; 5(1): 13-15. doi: 10.17140/EPOJ-5-119
