Hereditary Contribution Towards Development of Type 2 Diabetes Mellitus among Indian Population
At present, there is a dramatic rise in the incidence of diabetes all over the world.
Less than 3% of the total disease, each of diabetes, asthma, and hypertension has
been reported among Hajjis during the period of Hajj.
The exact inheritance pattern of this disease as for whether it is transmitted
through the paternal side or maternal side is not found.
Family history has been considered as one of the risk factors of diabetes.
Congregation of information on family history of disease for assessing the risk
has been used very less in the practice of preventive medicine and early detection.
In order to encourage change in lifestyle and initiate interventions of the disease,
medical guidelines mostly include family history as the use of this tool was more advantageous over
other genomic tools.
In India, the studies regarding the effect of positive family history of diabetes are still required.
The inheritance pattern of type 2 diabetes is quite complex to understand because many other factors are also affecting this disease such as lifestyle patterns, physical activity status, dietary habits etc.
and also the environmental factors. These complex relationships between genetic factors and environmental conditions may be reflected by tracing family history.
Till date, molecular genetics could not find out successfully the genetic markers of this disease.
Type 2 diabetes is known to be a heritable condition but no specific gene has been found for the common form
of diabetes. The relative contributions of paternal and maternal influences could provide information about the parental effects on their children and hence study of the parental transmission
of diabetes would be very valuable.
Diabetes Res Open J. 2019; 5(1): 18-22. doi: 10.17140/DROJ-5-141
