Investigation of Uric Acid and Cystatin C on Low-Carbohydrate Diet (LCD)
continued for long in the light of calorie restriction and low-carbohydrate diet.
Several researcher showed the predominant efficacy of LCD compared with CR.
Recently, Bernstein and Feinman have suggested adequate definition and
treatment of LCD, in addition to the statement of American Diabetes Association.
In Japan, authors and colleagues have treated lots of patients with diabetes mellitus,
and investigated the efficacy of LCD.
For medical and social development of LCD, we proposed 3 types of actual LCD in daily life,
which are petit, standard and super LCD. We have also reported the significant
role of ketone bodies in LCD and physiological role for pregnant
female and fetus newborn axis.
Furthermore, we investigated the clinical significance of Morbus value in the treatment of
LCD for the patients with type 2 diabetes mellitus.
M-value is useful marker in the evaluation for blood glucose variability in diabetic patients
that expresses both elevated glucose level and increased mean
amplitude of glycemic excursions.
When glycemic control gets better, numerical value of M-value decreases highly,
which is simple and helpful for clinical and medical practices
and research.
n this study, we have treated T2DM patients for super
LCD and investigated the changes of average blood glucose,
M-value and renal biomarkers such as uric acid, creatinine and
Cystatin C.
The subjects were 93 patients with T2DM, including 41 males and 52 females,
with 58.3±13.2 years old, and 60 years in median value.
They were admitted for 14 days, and received the same treatment protocol for endocrine,
metabolic and renal examination.
Diabetes Res Open J. 2017; 3(2): 31-38. doi: 10.17140/DROJ-3-133
