Microgenderome: An Important Variable for Developing Therapeutic Strategies?

Ravichandra Vemuri and Rohit Gundamaraju*

Microgenderome: An Important Variable for Developing Therapeutic Strategies?

A close association of microbiota in human health continues to emerge.
Microbiota has been implicated in autoimmune disorders such as type I
diabetes mellitus, inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis.

This is pointing out that early-life microbial exposure could be linked to later-life
susceptibility to immune-mediated disorders.

From the experimental models related to autoimmune disorders,
it is known that tissue injury is prevented by alteration in microbiota
or in germ-free condition.

Therefore, microbial alteration can be beneficial during
autoimmune disorders. However, several lines of evidence suggest
the role of gender-bias, in numerous diseases.

This editorial aims to throw light on the novel, emerging triangular relationship between host microbiota, sex hormones and immune responses cumulatively termed as “Microgenderome.

Numerous studies have reported that males are more susceptibility to microbial infections than females. This elevated susceptibility in males could be due to differential modulation of immune response by sex-hormones compared to females, indicating the role of sex-hormones in host-microbial interactions.

The study revealed presence of sex-specific microbial composition and their expansion in
absence of innate immune responses thereby demonstrating the
link between gut microbes, gender and immunity.

Gastro Open J. 2018; 3(1): e4-e5. doi: 10.17140/GOJ-3-e005

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