Changes of Fat Volume and Adipocytokines by the Randomized Intervention Program for Obesity Control Program (SCOP)
Adipocytokines are bioactive substances synthesized and secreted by fat cell.
Previous studies have reported an association between weight loss and adipocytokines.
However, these studies are inconsistent and they have not clarified the relationship
between weight regain and changes in circulating levels of adipocytokines.
In this study, we analyzed the relationship between weight and fat volume changes and adipocytokines.
The subjects were 235 obese people recruited in the Saku Control Obesity Program (SCOP).
Participants were randomly assigned to either immediate (Group A) or delayed (Group B, control group).
Group A participants were followed for another two years after completion of the one year intervention.
As controls, Group B participants received the same intervention as Group A after a delay of one
year. Then they were followed up for one year. The intervention consisted in a one-year lifestyle program to induce weight loss, based on a cognitive-behavioral approach.
After the first year of the study, body weight, Body Mass Index (BMI),
body fat and abdominal fat areas were significantly lower in group A participants,
compared to controls. After the intervention, leptin levels were significantly lowered both
in men and women. After one year follow-up, both men and women re-gained about 1.5 kg body weights on average.
Diabetes Res Open J. 2015; 1(5): 136-146. doi: 10.17140/DROJ-1-122