Radio Histological Treatment of Endometrial Hyperplasia: A Case Report

Priscila F. Berganza*, Maria D. Molina, María A. P. Dahinten and Mariela S. Ramos

Radio Histological Treatment of Endometrial Hyperplasia: A Case Report.

Endometrial hyperplasia is considered the most common precursor of gynecological cancer
diagnosed in women. The incidence of endometrial hyperplasia is indistinctly reported
to be around 200,000 new cases per year in Western countries, this is
caused by a disordered proliferation of the endometrial glands that
are the result of unopposed estrogenic stimulation of endometrial tissue with
compensatory progesterone deficiency.

The average age of diagnosis is in postmenopausal women between
the ages of 50-54-years. Endometrial
hyperplasia the most common cause of abnormal uterine bleeding leading to endometrial
cancer; if not treated in time, 10% of these patients’ histological results show endometrial hyperplasia.

The main function of endometrial sampling in patients with abnormal uterine bleeding is to determine
whether there are carcinomatous or premalignant lesions to decide the most appropriate management. The risk
factors for developing endometrial cancer involved are obesity,
estrogen therapy, diabetes, hypertension, polycystic ovarian syndrome, Lynch syndrome, treatment, and nulliparity.

Endometrial hyperplasia represents a continuum of histologically
distinct processes, starting from simple endometrial hyperplasia
without atypia and then progress to complex endometrial hyperplasia with atypia,
followed by well-differentiated endometrial carcinoma.

The presence and severity of cytological
atypia and architectural crowding are key factors defining the risk for progression to carcinoma. Simple hyperplasia shows the lowest risk of cancer
progression. Among patients with atypical hyperplasia, postmenopausal status is associated with the highest risk of progression to
adenocarcinoma.

Radiol Open J. 2020; 4(2): 55-58.doi: 10.17140/ROJ-4-132

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