Reduced Sampling Schedules for Calculation of an Insulin Sensitivity Index from the Liquid Meal Tolerance Test
The Matsuda composite index of insulin sensitivity has been widely used
as a measure of whole body insulin sensitivity in clinical and epidemiological research.
Recently, reduced sampling schedules for calculation of the MISI from an Oral Glucose
Tolerance Test have been shown to produce values that correlate well with insulin sensitivity
measured by the euglycemic clamp method.
However, a mixed meal represents a more physiologic stimulus than an oral glucose load.
Because insulin resistant states are associated not only with disturbances in carbohydrate
metabolism, but also with disturbances in postprandial lipid and hormonal responses,
a mixed meal stimulus allows assessment of additional variables of potential interest
such as postprandial triglyceride, incretin and appetite regulation hormone responses.
These variables change minimally in response to a glucose-only stimulus.
Additionally, a liquid meal allows for simpler standardization across research sites,
particularly research sites in different countries, where it may be difficult to obtain standard
products for a solid meal test.
Therefore, the objective of this study was to evaluate the performance of the MISI
derived from Liquid Meal Tolerance Test data, calculated using reduced sampling
schedules, compared with the insulin sensitivity index derived from minimal model analysis
of data from an insulin-modified Intravenous glucose tolerance test in overweight and obese subjects
Diabetes Res Open J. 2015; 1(1): 24- 26. doi: 10.17140/DROJ-1-104