Dear Readers,

Rare non-squamous cell head and neck cancers constitute a wide range of tumors such as lymphomas, plasmacytomas, sarcomas, and neuroendocrine tumors. Although during the last two decades, substantial progress has been witnessed in the classification and understanding of the clinical behavior of rare non-squamous cell head and neck cancers, many unresolved issues regarding their epidemiology, treatment, and prognosis still exist. In this edition, we will elaborate on those rare cancers arising in the head and neck region, trying to discover hidden clinical concerns with respect to their epidemiology and optimal treatment.