The Evolving Field of Stereotactic Body Radiation Therapy in Pancreatic Cancer

Maged Ghaly*, Emile Gogineni and Muhammad W. Saif

The Evolving Field of Stereotactic Body Radiation Therapy in Pancreatic Cancer.

Pancreatic cancer remains a devastating disease with dismal outcomes despite the development of novel chemotherapeutic regimens and
radiation techniques. Stereotactic body radiation therapy offers an advantage both in image guidance and
radiation dose delivery to direct ablative doses to tumors with acceptable toxicity compared to conventional techniques.

Recent literature is clustered with data pertaining to SBRT in patients with resectable, borderline
resectable and locally advanced pancreatic tumors. We here present a summary of the current data and highlight the limitations and potential for future growth.

Further clinical study in the form of multi-institutional trials is warranted to establish the role
of SBRT in combination with new chemotherapeutic agents as well as a
non-invasive alternative to surgery.

Pancreatic ductal adenocarcinoma is an aggressive malignancy with limited effective therapeutic options and exceedingly
high mortality. Currently, a cure may be achieved through resection; recent evidence
suggests that neoadjuvant therapy can increase R0 resection rates with effective local
control.

Stereotactic body radiation therapy has garnered significant interest for pancreatic cancer patients as it is completed quickly
over 1-5 fractions, requires less time away from full doses of chemotherapy, and is generally
much better tolerated than conventional radiographic
testing as a result of more limited target
volumes.

Favorable results of SBRT for locally advanced pancreatic cancer patients are now leading to the
exploration of SBRT for other pancreatic cancer patients.

Pancreas Open J. 2019; 3(1): 9-14. doi: 10.17140/POJ-3-110

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