Wellness Fasting and Hyperketosis
Ketoacidosis is sometimes a lethal complication of diabetes mellitus.1-3 Ketone bodies
are considered to be the toxic elements of ketoacidosis.
Ketogenic food containing a high proportion of fat has been successfully used to treat epileptic
fits resistant to medication. In a typical epilepsy diet, fat accounts for 90% of the energy intake.
Such meals bring about changes in the enterobacterial flora.
The production of adenosine triphosphate is the key to energy homeostasis.
In animal cells, glucose is successively transformed into pyruvic acid and acetyl coenzyme A or
acetyl-CoA, the latter entering the tricarboxylic acid cycle as a fuel.
The peripheral cells of various organs absorb acetoacetic acid to yield acetyl-coA and use it as fuel.
We have reported the case of a lady who has being living happily on one cup of green
vegetable juice per day for 18 years.
For example, the zinc-dependent mammalian histone-deacetylase family comprises 11 enzymes,
which have specific and critical functions in embryonic development and tissue homeostasis.
Furthermore, βHB acts as a ligand to the G-protein coupled receptor GPR109,
which results in anti-inflammatory properties. These mechanisms could improve human
health through antioxidant and anti-inflammatory pathways protecting against arteriosclerosis,
myocardial damages, brain dysfunction, etc.
A ketone supplement has appeared in European and American supermarkets since the end
of 2014.22-24 It contains a diester of βHB and acetoacetic acid, βHB monoester,
and βHB salt with Na+ , K+ or Ca2+ ions. This is a potential cause of gastrointestinal
dysfunction and diarrhea. The excess intake of salt is also problematic.
In some clinical trials, the meal composition was 30% carbohydrates, 15% each of protein
and lipid, and 30% keton-ester. Athletes took 15.6 g of ketone supplement and exercised.
Diabetes Res Open J. 2016; 2(2): e10-e13. doi: 10.17140/DROJ-2-e007